Classification of lymphoreticular malignancies

Lymphoreticular dysfunction in idiopathic steatorrhoea.

Lymphoreticular diseases in Nigerians.

BACKGROUND The lymphoreticular system plays a major role in both the innate and adaptive immune responses. This study reviews retrospectively cases of lymphoreticular diseases seen at a tertiary institution in Nigeria. MATERIALS AND METHODS This is a retrospective study in which biopsies from the bone marrow, spleen, lymph nodes and extranodal lymphoid tissues reported within a period of 16 y...

Whole-exome sequencing enhances prognostic classification of myeloid malignancies

PURPOSE To date the standard nosology and prognostic schemes for myeloid neoplasms have been based on morphologic and cytogenetic criteria. We sought to test the hypothesis that a comprehensive, unbiased analysis of somatic mutations may allow for an improved classification of these diseases to predict outcome (overall survival). EXPERIMENTAL DESIGN We performed whole-exome sequencing (WES) o...

Myasthenia gravis, haemolytic anaemia, and lymphoreticular malignancy.

DISCUSSION Adipose tissue from the adult diabetics tested in this study shows a pronounced reduction in activity of phosphofructokinase. This appears even when the enzyme is maximally activated by sulphate ions and suggests that there is an absolute reduction in level of enzyme protein. Phosphofructokinase is an enzyme which is thought to exert control over glycolysis by activation/inhibition r...

Extraneural prion neuroinvasion without lymphoreticular system infection.

While prion infection of the lymphoreticular system (LRS) is necessary for neuroinvasion in many prion diseases, in bovine spongiform encephalopathy and atypical cases of sheep scrapie there is evidence to challenge that LRS infection is required for neuroinvasion. Here we investigated the role of prion infection of LRS tissues in neuroinvasion following extraneural inoculation with the HY and ...